Hello,
the main advantage of cat12 over current spm segmentation approaches is
that is relies less on the tissue probability maps. Within spm, a
combination of intensity ("does it look like gray matter") and location
("is it where I am expecting gray matter") is used, the latter being
influenced by the priors you use.
Re: your project: if you look at the natural growth curve of the brain,
you will be surprised (or not) to see that a 10 year-old's brain
actually has quite a bit more GM than the average adult. This, in a
combined approach, should be reflected in the priors. In an
intensity-driven approach (such as cat12), this will be less relevant,
but priors are still used for spatial normalization and should thus also
be appropriate for the population under study.
Cheers
Marko
F Sadeghian schrieb:
> Dear SPM experts,
>
> I want to do VBM on a cohort of 9-10 years old kids. I was reading your posts regarding VBM8 and then CAT12 which helps to do VBM, but I was not sure the advantage of these tools than routine VBM analysis steps (just change default TPM to TOM8 template that is generated separately using our cohort) and using DARTEL template to do population template in own space. I am confused now and your advice would be very much appreciated.
>
> Thank you in advance for your time,
> Farnoosh
>
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Prof. Dr. med. Marko Wilke
Facharzt für Kinder- und Jugendmedizin
Leiter, Experimentelle Pädiatrische Neurobildgebung
Universitäts-Kinderklinik
Abt. III (Neuropädiatrie)
Marko Wilke, MD, PhD
Pediatrician
Head, Experimental Pediatric Neuroimaging
University Children's Hospital
Dept. III (Pediatric Neurology)
Hoppe-Seyler-Str. 1
D - 72076 Tübingen, Germany
Tel. +49 7071 29-83416
Fax +49 7071 29-5473
[log in to unmask]
http://www.medizin.uni-tuebingen.de/kinder/epn/
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