Dear all administering HBV courses in an NHS occupational health setting,
please can you advise as to what schedule you follow bearing in mind the following paragraph taken from the Green Book?
Pre-exposure prophylaxis For pre-exposure prophylaxis in most adult and childhood risk groups, an accelerated schedule should be used, with vaccine given at zero, one and two months. Only for those infants who are at continued risk, a fourth dose is recommended at 12 months. An alternative schedule at zero, one and six months should only be used where rapid protection is not required and there is a high likelihood of compliance. Higher completion rates are achieved with the accelerated schedule (at zero, one and two months) in groups where compliance is difficult (e.g. in IDUs and genito-urinary medicine clinic attenders) (Asboe et al., 1996). This improved compliance is likely to offset the slightly reduced immunogenicity when compared with the zero-, one- and six-month schedule, and similar response rates can be achieved by opportunistic use of a fourth dose after 12 months.
Thank you in advance.
Best wishes,
Sarah.
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