Hello,
from what I have seen, the lesions in NMDA receptor encephalitis (if
present at all) will be far less well-defined then a typical MS lesion.
Hence, an automated approach may systematically underestimate the one
lesion type. In a scenario like this, estimating lesion load may be
"better", albeit a bit more laborious, if done semi-automatically. For
this, you could use the Clusterize toolbox which will do some automated
preprocessing using some spm functions, and then allows you to
interactively select and delineate your areas of interest. It was
developed for demyelinating diseases so WM lesions are right down its
alley ;) You can find it at
www.medizin.uni-tuebingen.de/kinder/en/research/neuroimaging/software/
Cheers
Marko
Jeff Browndyke wrote:
> Lesion Segmentation Toolbox for SPM using the Lesion Prediction
> Algorithm (LPA) is where I would start for any MS lesion determination /
> masking need.
>
> Jeff
>
> -----------------------
> Jeff Browndyke, PhD
> Duke University Medical Center
>
> Sent from my iPhone
>
> On Jun 18, 2017, at 9:43 AM, Paul Chang <[log in to unmask]
> <mailto:[log in to unmask]>> wrote:
>
>> Hello everyone :)
>>
>> I am Paul, from Taiwan, and I am now a MRes student at UCL Institute
>> of Neurology.
>>
>> I am going to start a project about *differentiating the "white
>> matter" demylination regions in MS and anti-NMDA receptor encephalitis
>> patients.* The software I am self-learning now and going to use will
>> be *FSL.* And the images I will obtain are the *T2/FLAIR* and *T1 GAD*
>> images.
>>
>> My idea will be using the *FAST Segmentation* and *FSL-VBM* (in FLIRT
>> lineary registration toolbox) to calcuate the area of demylination
>> regions.
>>
>> Since I am still quite new in this field, I would like to get some
>> advice about whether my thoughts are reasonable and whether there is
>> any other practical way (either in FSL or SPM) to process those
>> images. Many Thanks
>>
>> Best Wishes
>>
>>
>> Pao-Sheng Chang
>> MRes Translational Neurology 2016/17 year at UCL Institute of Neurology
>>
--
____________________________________________________
Prof. Dr. med. Marko Wilke
Facharzt für Kinder- und Jugendmedizin
Leiter, Experimentelle Pädiatrische Neurobildgebung
Universitäts-Kinderklinik
Abt. III (Neuropädiatrie)
Marko Wilke, MD, PhD
Pediatrician
Head, Experimental Pediatric Neuroimaging
University Children's Hospital
Dept. III (Pediatric Neurology)
Hoppe-Seyler-Str. 1
D - 72076 Tübingen, Germany
Tel. +49 7071 29-83416
Fax +49 7071 29-5473
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http://www.medizin.uni-tuebingen.de/kinder/epn/
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