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MEDICAL: DISEASES: MULTIPLE SCLEROSIS :
MEDICAL: RESEARCH :
MEDICAL: PHARMACY PHARMACEUTICAL PHARMACOLOGY: DRUGS:
New Multiple Sclerosis Drug,
Backed by 40 Years of Research, Could Halt Disease
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New Multiple Sclerosis Drug,
Backed by 40 Years of Research, Could Halt Disease
March 29, 2017
by Nina Bai
Medical Xpress
https://medicalxpress.com/news/
2017-03-multiple-sclerosis-drug-years-halt.html
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A shorter URL for the above link:
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http://tinyurl.com/mnrcbmq
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A newly approved drug that is the first to reflect the current scientific
understanding of multiple sclerosis (MS) is holding new hope for the
hundreds of thousands Americans living with the disease.
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It also highlights the importance of clinician-scientists like UC San
Francisco's Stephen Hauser, MD, who are working to transform research into
cures for patients.
The Food and Drug Administration on Tuesday approved ocrelizumab (brand
name Ocrevus) to treat both relapsing-remitting MS and primary progressive
MS, the first time a therapy has been available for severe forms of the
disease.
The drug, the first that targets B cells in the human body, grew out of
the work of Hauser, chair of neurology at UCSF, whose team persevered for
decades in elucidating the science behind MS, defending findings that
contradicted long-standing assumptions and translating the science into a
therapy.
A Devastating Disease
In MS, the immune system attacks the protective myelin covering around
nerve cells, stripping them like insulation from electrical wires. We now
know, thanks in large part to Hauser and his colleagues, that immune cells
known as B cells lead the attack, mistaking myelin protein for harmful
agents. The attacks cause inflammation that disrupts the communication
between nerve cells.
The first episode of MS typically strikes in early adulthood and the
disease advances over the years to devastating disability. Depending on
where the inflammation occurs the brain, spinal cord or optic nerves
patients can develop muscle weakness, incoordination, bladder
difficulties, visual impairment and cognitive problems.
In relapsing-remitting MS, the most common form, people experience
intermittent flares of symptoms followed by periods of complete or partial
recovery.
About one in 10 people with MS have the more intractable primary
progressive form and experience steady worsening of symptoms without
remission.
There are no cures for MS, and existing treatments only partially reduce
symptoms of relapsing-remitting MS. No therapies at all have been
effective for primary progressive MS until now. The approval of the
ocrelizumab comes after studies that have shown remarkable results for
both forms of the disease.
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snip
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Topics Discussed in This Article
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The Promise of the New Drug
Hope for Patients
Finding a Better Model
A Second Eureka Moment
Importance of Clinician-Scientists
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Positive multiple sclerosis clinical trial suggests 'unprecedented'
effects in relapsing form of the disease
https://medicalxpress.com/news/
2016-12-positive-multiple-sclerosis-clinical-trial.html
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A shorter URL for the above link:
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http://tinyurl.com/k5wk9l4
More information: Xavier Montalban et al. Ocrelizumab versus Placebo in
Primary Progressive Multiple Sclerosis, New England Journal of Medicine
(2017). DOI: 10.1056/NEJMoa1606468
https://medicalxpress.com/journals/new-england-journal-of-medicine/
Journal reference: New England Journal of Medicine
Provided by: University of California, San Francisco
http://tinyurl.com/k5wk9l4
http://dx.doi.org/10.1056/NEJMoa1606468
http://tinyurl.com/lsv48zy
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David Dillard
Temple University
(215) 204 - 4584
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