Dear Darren,
please note that only for the creation of a customized TPM for the TOM9 toolbox the low-dimensional SPM12 normalization approach is used. This TPM is only used for the initial affine registration. However, a DARTEL normalization is recommended for the subsequent spatial registration anyway.
If you intend to analyze children and parents in one analysis together you should also use the same (DARTEL) template. In that case I recommend to create a customized DARTEL template based on all children and parents.
Best,
Christian
On Sun, 4 Dec 2016 17:38:13 +0000, Darren Yeo <[log in to unmask]> wrote:
>Dear all,
>
>I am attempting to run a VBM analysis with child-parent dyads using CAT12/SPM12, and I have some concerns about the normalization approach I should adopt.
>
>I was thinking of the following:
>For children (n = 20) - Create a customized Tissue Probability Map using TOM8 toolbox, use low-dimensional SPM12 normalization approach (as suggested in CAT12 manual p. 42)
>For adults (n> 50) - Use the SPM12 Tissue Probability Map, use the SPM12's DARTEL template in MNI space
>
>Eventually I would like to correlate the two groups, and I was wondering if the above approach would be ideal, or should I use the SPM12's DARTEL template in MNI space for children for normalization too? I'm aware that I do not have a sufficiently large sample (n > 50) to create a customized DARTEL template for the children.
>
>I would appreciate any suggestions or advice!
>
>Thank you.
>
>Best,
>Darren
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