Reply-To: | | [log in to unmask][log in to unmask]> wrote: > > Dear SPMers, > > I have performed an fMRI experiment to activate brown fat in the shoulders. The experiment is not of the typical fMRI type, with multiple blocks of activation and baseline conditions. The participant wears a special suit with plastic tubes on it, through which water is circulated. The experiment starts with the baseline condition - warm water. After 10 minutes the water is switched to cold water, and this condition lasts for about 50 minutes. fMRI images of the shoulder are simultaneously acquired during water circulation. > I would like to compare the last 20 minutes of cold water condition (along with other range of cold water conditions) to the first 10 minutes of warm water condition. > I don’t think I can use HRF as basis function to model this design to compare the active versus baseline condition, as the stimulus is constantly ON. Can I perform two sample t-test comparisons of images obtained during the active versus baseline conditions, instead of performing the first level analysis, to localize the activations in response to cold? Any help with this analysis is greatly appreciated. > > Many thanks! > > Binu > > > UT Southwestern > > Medical Center > > The future of medicine, today. >[log in to unmask] |