Hello,
> I also have one more question/problem
Only one? ;)
> I have used the TOM toolbox and have a children's template.
OK.
> the template is created from typically developing population and one of my
> groups is autistic,I would like to control for the effects of Total
> Intra Cranial Volume
OK.
> But to estimate TIV I would need a template for segmentation
Yes, but why can you not use TOM's tpm for segmentation? That would
actually be the idea behind it.
> and a template with TIV as a covariate would be better
> suited to the population(I assume)-Which is kind of circular.
I am not sure I follow you. You want to use an externally generated
template which is not biased towards either of your groups, which is
going to be hard if the one group has a disease and the other does not.
One way out would be to generate your own template from your dataset but
I mentioned before that you would need a very large group for this, the
larger the more diverse your population is. Another approach would be to
take this potential bias into account by looking at (for example) TIV
between your groups and potentially use it as a covariate later-on,
which is what I think is what you are planning to do. Why you would need
the TIV of the template, I did not quite get but you could of course
calculate each tissue class volume in the 6-volume TPM that TOM gives
you... was that what you were asking?
> Kindly comment on the same
I did, but I am not sure this helped...?
Cheers
Marko
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____________________________________________________
Prof. Dr. med. Marko Wilke
Facharzt für Kinder- und Jugendmedizin
Leiter, Experimentelle Pädiatrische Neurobildgebung
Universitäts-Kinderklinik
Abt. III (Neuropädiatrie)
Marko Wilke, MD, PhD
Pediatrician
Head, Experimental Pediatric Neuroimaging
University Children's Hospital
Dept. III (Pediatric Neurology)
Hoppe-Seyler-Str. 1
D - 72076 Tübingen, Germany
Tel. +49 7071 29-83416
Fax +49 7071 29-5473
[log in to unmask]
http://www.medizin.uni-tuebingen.de/kinder/epn/
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