Dear Natan,
When loading an image via the "Display" function you indeed have different interpolation options - these are for visualization purpose only though, the files remain unaltered. As your slice thickness is rather large (3 mm) relative to the in-plane resolution (0.417 x 0.417) the raw image might look "boxy" along one dimension without any interpolation, but that's just the way the file was acquired / reconstructed.
Whether and if so, how to deal with that depends on the purpose. If it were a group study you might want to warp the different subjects' images onto a template image, then apply some smoothing to account for remaning inaccuracies between subjects. During those steps the files would be interpolated anyway, and you could also specify a different and if desired, a more isotropic voxel size.
Hope this helps
Helmut
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