Dear Varun,
in addition to Marko's answer you should keep in mind that due to the huge age range your disease effects might be difficult to investigate because the effects due to development might be much larger and overlayed onto it. Without having healthy control subjects it might be difficult to investigate disease effects either.
Best,
Christian
On Wed, 10 Aug 2016 16:16:09 +0200, Marko Wilke <[log in to unmask]> wrote:
>Hello,
>
>Cyril was just a bit faster than me :)
>
>One more note: the age range you are
>investigating is huge, and any template that you use will not fully
>reflect the contribution from the ends of the spectrum. If this cannot be helped, I would
>suggest looking into the TOM8 toolbox that you can download from the IRC
> website (don't forget to also download the regression parameters). With this toolbox, you can create a matched template to the average age and
> gender composition of your sample. Note that you cannot enter the ages
>of all subjects ("matched pairs") as 3 year olds will be below the age range originally
>assessed, but the average age will also work.
>
>A better way may be to
> generate a template based on your own subjects, but only if you have
>several hundreds of them. Also, spatial normalization will only be one of your problems, segmentation (which now usually is the basis for normalization) will likewise be an issue.
>
>Cheers
>Marko
>
>
>
>
>--
>____________________________________________________
>Prof. Dr. med. Marko Wilke
> Facharzt für Kinder- und Jugendmedizin
> Leiter, Experimentelle Pädiatrische Neurobildgebung
> Universitäts-Kinderklinik
> Abt. III (Neuropädiatrie)
>
>Marko Wilke, MD, PhD
> Pediatrician
> Head, Experimental Pediatric Neuroimaging
> University Children's Hospital
> Dept. III (Pediatric Neurology)
>
>Hoppe-Seyler-Str. 1
> D - 72076 Tübingen, Germany
> Tel. +49 7071 29-83416
> Fax +49 7071 29-5473
> [log in to unmask]
>
> http://www.medizin.uni-tuebingen.de/kinder/epn/
>____________________________________________________
>
>
>>>> Varun Chandran <[log in to unmask]> 08/10/16 1:50 PM >>>
>Hi SPM experts,
>
>I am working on the MR brain Imaging study on Autism spectrum disorder in children between the age group of 3 - 19 years old,where we do not acquire healthy control data. I'm facing a challenge in getting a age specific pediatric brain templates of rs-fMRI,T1-W structural and Tissue probability maps for performing spatial normalization using SPM8. Any suggestions would be encouraged and appreciated.
>
>Thank you very much for your valuable time and consideration.
>
>regards,
>Varun AC
>
>
>
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