Dear FSL users,
I have a question regarding the effect of hemoglobin level in BOLD signal.
We are trying to investigate the resting-state fMRI change during the pre- and post-medication.
The problem is that after the medication, few number of participants has shown hemoglobin level change.
According to the previous studies, (Yang, Front Neurosci. 2015 doi: 10.3389/fnins.2014.00452) (Levin, Magn Reson Imaging. 2001 Oct;19(8):1055-62) hemoglobin level influences BOLD signal.
However, we want to see the pure effect of medication on the resting-state brain network.
I planning to put the hemoglobin level as covariate during the 2nd level anaylsis to overcome this problem.
Is there anyone who struggled with the similar problem?
If you have, how did you deal with it?
I tried to find a paper which has solved the problem, but I couldn't.
Are there any publication which overcome this problem?
I appreciate your help in advance.
Best,
YW
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