Dear users,
I would like to know the minimum protein:ligand ratio
that will yield a cocrystal, provided there are some
binding values from biophysical techniques.
Suppose, biophysical techniques like MST shows a binding
when molar ratio of protein:ligand is greater than 1:500,
is it necessary to have this ratio while co-crystallizing?
I have previous experiences in which I had obtained
ligand bound structure when I used 1:10 to 1:30 (molar
ratio). But, it is not working now.
Thank you
Regards
Kavya
--
This message has been scanned for viruses and
dangerous content by MailScanner, and is
believed to be clean.
|