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MEDICAL: DISEASES: KIDNEY :
MEDICAL: PHARMACY PHARMACEUTICAL PHARMACOLOGY: DRUG:
ADVERSE EVENT: PROTON-PUMP INHIBITORS (PPIS) :
RISK:
Popular Acid Reflux Drugs Are Linked To Kidney Disease Risk
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Popular Acid Reflux Drugs Are Linked To Kidney Disease Risk
Updated January 11, 20168:58 PM ET
Published January 11, 201611:19 AM ET
Rob Stein
NPR
http://www.npr.org/sections/health-shots/2016/01/11/462423759/
popular-acid-reflux-drugs-are-linked-to-kidney-disease-risk
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A shorter URL for the above link:
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http://tinyurl.com/h9whe2a
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People who take certain popular medicines for heartburn, indigestion and
acid reflux may want to proceed more cautiously, researchers reported
Monday.
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The drugs, known as proton-pump inhibitors (PPIs), appear to significantly
elevate the chances of developing chronic kidney disease, according to a
study involving more than 250,000 people.
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An estimated 15 million Americans use PPIs, which are sold by prescription
and over-the-counter under a variety of brand names, including Nexium,
Prilosec and Prevacid.
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"They're very, very common medications," says Morgan Grams, an
epidemiologist at the Johns Hopkins Bloomberg School of Health who led the
research, being published in the journal JAMA Internal Medicine.
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When PPIs were first approved in the 1980s, the drugs appeared to be very
safe. Since then, concerns have been rising about their safety. Evidence
has emerged that the drugs may increase the risk for a variety of
problems, including bone fractures, infections and possibly even heart
problems.
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Grams and her colleagues decided to examine whether PPIs might increase
the risk for chronic kidney disease. They examined the medical records of
two groups of people: 10,482 participants in the Artherosclerosis Risk in
Communities (ARIC) study and 248,751 patients in the Geisinger Health
System in Pennsylvania.
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Among the 322 people using PPIs in the ARIC study, the 10-year estimated
absolute risk for chronic kidney disease was 11.8 percent, the researchers
reported. The expected risk would have been 8.5 percent. The 10-year
absolute risk among the 16,900 patients using PPIs in the Geisinger Health
System was 15.6 percent, whereas 13.9 percent would have been expected to
develop chronic kidney disease.
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The complete article may be read at the URL above.
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Temple University
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