Hello.
I would like some clarification please to get my mind around this.
I have data from a two time-point (pre-post) imaging study, where an intervention was given following an initial scan, then participants were rescanned after receiving the intervention. I have pre and post measures of processing speed, which I want to look at.
In my GLM to apply to the VBM data, I have a continous EV which is the change in processesing speed (time 2 - time 1) and a 4D counfound EV which is the time-1 VBM data. Am I right in thinking that the results would show how individual responses to the intervention are linked to grey matter changes, but ignoring initial GM at time-1? Are there any particular caveats to conducting such an analysis?
Im sorry if this is a bit basic. Thank you for advising.
Sam.
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