Please draw the following to the attention of suitable candidates:
The group of Dr. Stephen Cusack at EMBL Grenoble is engaged in
structural and mechanistic studies of replication and transcription
by segmented negative strand RNA virus of human health interest, notably
influenza virus and bunyaviruses.
The approach encompasses structural studies by X-ray crystallography and
cryo-EM, mechanistic and functional studies in vitro and in cells,
including with polymerase host cell cofactors, and structure based
anti-viral drug design.
Recent breakthrough results by the group have been published in Nature
and Cell:
-Structural insight into cap-snatching and RNA synthesis by influenza
polymerase. Reich S. et al. Nature. 2014 PMID: 25409151
-Structure of influenza A polymerase bound to the viral RNA promoter.
Pflug A et al. Nature. 2014 PMID:25409142
-Structural insights into bunyavirus replication and its regulation by
the vRNA promoter. Gerlach et al. Cell. 2015 PMID:26004069.
The candidate will work on structural and functional aspects of the
mechanism and regulation of RNA synthesis by bunyavirus RNA polymerase
building on the structural data and extensive knowhow now available in
the laboratory.
He/She should have a PhD in structural molecular biology, an interest in
understanding the molecular mechanisms of RNA virus replication and
ideally experience in one or more of the following: expression and
purification of large complexes in insect cells, biochemistry of
protein-RNA complexes and high resolution structural analysis.
An initial contract of two years will be given to the successful candidate.
Please apply online through www.embl.org/jobs; Reference Number: GR_00084
Additional information is available from Dr. Stephen Cusack ([log in to unmask])
The European Molecular Biology Laboratory (EMBL) is one of the highest
ranked scientific research organisations in the world.
The Headquarters Laboratory is located in Heidelberg (Germany), with
additional sites in Grenoble (France),
Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy).
EMBL is an inclusive, equal opportunity employer offering attractive
conditions and benefits appropriate to an international research
organisation.
Please note that appointments on fixed term contracts can be renewed,
depending on circumstances at the time of the review.
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Dr. Stephen Cusack, FRS
Head of Grenoble Outstation of the European Molecular Biology Laboratory (EMBL)
Group leader in structural biology of protein-RNA complexes and viral proteins
Director of CNRS-UJF-EMBL International Unit (UMI 3265) for Virus Host Cell Interactions (UVHCI)
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Email: [log in to unmask]
Website: http://www.embl.fr
Tel: (33) 4 76 20 7238 Secretary (33) 4 76 20 7123
Fax: (33) 4 76 20 7199
Postal address: EMBL Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France
Delivery address: EMBL Grenoble Outstation, Polygone Scientifique, 71 Avenue des Martyrs, 38000 Grenoble, France
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