The Hoelz laboratory at the California Institute of Technology seeks to recruit an outstanding postdoctoral scientist in structural biology. Our laboratory focuses on the structure-function relationships of multi-protein macromolecular assemblies with a focus on the nuclear pore complex and nucleocytoplasmic transport.

This position requires a recent Ph.D. degree in biochemistry/biophysics with a strong background in x-ray crystallography. The successful applicant should be a highly motivated individual with good organizational, communication, and interpersonal skills, who is able to carry out a structure determination project from the development of recombinant protein expression systems to structure refinement. Experience with functional in vivo assays would be a plus but is not required.

The laboratory is newly constructed, well-funded, and equipped with modern biophysical instrumentation and current crystallization robotics. Importantly, Caltech has an exceptional infrastructure for macromolecular crystallography, including 40 % access to a high intensity, completely automated, state-of-the-art crystallography beamline equipped with a PILATUS detector at the Stanford Synchrotron Radiation Lightsource (SSRL).

The position is available immediately and funded for several years.

To apply, please send your CV, a statement of research interests, and the names and contact information of at least two references to André Hoelz ([log in to unmask]).


Selected Publications

Stuwe, T.,# Bley, C.J. ,# Thierbac, K., # Petrovic, S., # Schilbach, S., Mayo, D.J., Perriches, T., Rundlet, E.J., Jeon, Y.J., Collins, L.N., Huber, F.M., Lin, D.H., Paduch, M., Koide, A., Lu, V., Fischer, J., Hurt, E., Koide, S., Kossiakoff, A., Hoelz, A.* (2015). Architecture of the fungal nuclear pore inner ring complex, Science, Epub ahead of print

Stelter, P.,# Huber, F.M.,# Kunze, R., Flemming, D., Hoelz, A.*, Hurt, E.*  (2015). Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribosome Is Regulated by Its Eukaryote-Specific Extension, Mol. Cell, 58, 854-862. [COVER]

Stuwe, T.S.,# Correia, A.R.,# Lin, D.H., Paduch, M., Lu, V.T., Kossiakoff, A., Hoelz, A.* (2015). Architecture of the nuclear pore complex coat, Science, 347, 1148-1152.

Davenport, A.M., Collins, L.N., Chiu, H., Minor, P.J., Sternberg, P.W., Hoelz, A.* (2014). Structural and Functional Characterization of the α-tubulin acetyltransferase MEC-17 J. Mol. Biol. 426, 2605-2616.

Stuwe, T.S., Lin, D. H., Collins, L.M., Hurt, E., Hoelz, A.* (2014). Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins, Proc. Natl. Acad. Sci. USA 111, 2530-2535. 

Davenport, A.M., Huber, F.M., Hoelz, A.* (2014). Structural and Functional Analysis of Human SIRT1, J. Mol. Biol. 426, 526-541. [COVER]

Lin, D.H., Zimmermann, S., Stuwe, T.S., Stuwe, E., Hoelz, A.* (2013). Structural and Functional Analysis of the C-terminal Domain of Nup358/RanBP2, J. Mol. Biol. 425, 1318-1329.  [COVER]

Stuwe, T.S., Schada von Borzyskowski, L., Davenport, A.M., Hoelz, A. (2012). Molecular Basis for the Anchoring of Proto-Oncoprotein Nup98 to the Cytoplasmic Face of the Nuclear Pore Complex, J. Mol. Biol. 419, 330-346. [COVER]

Yoshida, K., Seo, H.S., Debler, E.W., Blobel, G., Hoelz, A. (2011). Structural and functional analysis of an essential heterotrimer on the cytoplasmic face of the nuclear pore complex, Proc. Natl. Acad. Sci. USA 108, 16571-16576.

Hsia, K.C., Hoelz, A. (2010). Crystal structure of α-COP in complex with ε-COP provides insight into the architecture of the COPI vesicular coat. Proc. Natl. Acad. Sci. USA 107, 11271-11276.

Ren, Y., Seo, H.S., Blobel, G., Hoelz, A. (2010). Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. Proc. Natl. Acad. Sci. USA 107, 10406-10411.

Nagy, V., Hsia, K.C., Debler, E.W., Kampmann, M., Davenport, A.M., Blobel, G., Hoelz, A. (2009). Structure of a trimeric nucleoporin complex reveals alternate oligomerization states. Proc. Natl. Acad. Sci. USA 106, 17693-17698.

Napetschnig, J., Kassube, S.A., Debler, E.W., Wong, R.W., Blobel, G. and Hoelz, A. (2009). Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19. Proc. Natl. Acad. Sci. USA 106, 3089-3094.

Debler, E.W., Ma, Y., Seo, H.S., Hsia, K.C., Noriega, T.R., Blobel, G., Hoelz, A. (2008). A fence-like coat for the nuclear pore membrane. Mol. Cell 32, 815-826. [COVER]

Hsia, K.C., Stavropoulos, P., Blobel, G., Hoelz, A. (2007) Architecture of a coat for the nuclear pore membrane. Cell 131, 1313-1326.

Melcak, I., Hoelz, A.*, Blobel, G.* (2007). Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding. Science 315, 1729-1732.