Dear Bernhard,
I think you need to clarify the first question. “Denied funding’ means to me that a committee officially denied the proposal for these reasons, which is rare, as typically they are very careful, or at least that is my experience. However, its rather common that one of the referees uses any of these as a negative point during a review.
Most importantly though, I think that these days almost any grant that is purely based on determining structures will be denied by definition. Thus I doubt if the question as it is posed now warrants investigation … I think the time for ‘crystallographic studies’ has passed and almost all grants that include structural work are in the context of a wider scientific framework...
best
Tassos
> Were you denied funding for a structure study because you did not have yet
> (a) large scale protein expression
> (b) first crystals
> (c) diffraction crystals
> (d) data
> (e) maps
>
> Did you have to 'reverse engineer' an application, i.e. you had the
> structure already (almost) and
> then write the grant?
>
> Any other peculiarities/comments you received, and what you feel would need
> improvement/should be addressed.
>
> Again, any comments will be confidential and will contribute to raise
> awareness for the special
> requirements of, and funding for, the significant up-front work necessary
> for crystallographic studies.
> Get it off your soul and make the world a better place.
>
> Thanks and best regards, BR
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> Bernhard Rupp
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