Sure - crystallization selects what packs, which may constitute a very minor fraction of what you set up drops with. 1DUH is an example...
-Luca
> On Apr 8, 2015, at 15:08, Sebastiaan Werten <[log in to unmask]> wrote:
>
> Dear all,
>
> we are currently working on a protein that is known to exist in a monomer-dimer equilibrium. At the high concentrations used for crystallisation assays, the dimer is predominant and the monomer practically undetectable.
>
> Nevertheless, one of the crystal forms that we have obtained contains the monomeric species, not the dimer.
>
> I was wondering if anyone is aware of similar (published) cases, and if the phenomenon as such has been discussed in detail anywhere?
>
> I did literature searches but so far couldn't find anything.
>
> Any pointers would be much appreciated!
>
> Best wishes,
>
> Sebastiaan Werten.
>
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