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SPORTS MEDICINE :
MEDICAL: CONDITIONS:
OBESITY :
MEDICAL: DISEASES: CAUSES :
MEDICAL: GENETICS:
Obesity 'Not Always Linked with Metabolic Problems
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Obesity 'Not Always Linked with Metabolic Problems
David McNamee
Medical News Today (MNT)
http://www.medicalnewstoday.com/articles/287537.php
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In a new study, researchers have found that some obese people do not have
the metabolic changes usually associated with diabetes, heart disease and
stroke. This suggests that some obese people may be protected from these
metabolic abnormalities when gaining weight.
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snip
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To gain weight, the participants ate at fast-food restaurants, under the
supervision of a dietitian, at restaurants selected by the researchers on
the basis of their accurate reporting of nutritional information and
consistent portion sizes.
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snip
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The researchers identified some factors that distinguished the
metabolically normal obese participants from the participants with
metabolic problems.
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One of these key factors was the accumulation of fat inside the livers of
people with abnormal metabolism - people with normal metabolism did not
have these fat accumulations.
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Also, the participants with normal metabolism expressed more genes that
regulate the production and accumulation of fat than those with abnormal
metabolism. This gene activity increased when the metabolically normal
participants gained weight, but there was no increased activity in those
with abnormal metabolism.
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The complete article may be read at the URL above.
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J Clin Invest. doi:10.1172/JCI78425.
Copyright 2015, The American Society for Clinical Investigation.
Clinical Medicine
Metabolically normal obese people are protected from adverse effects
following weight gain
Elisa Fabbrini, Jun Yoshino, Mihoko Yoshino, Faidon Magkos, Courtney
Tiemann Luecking, Dmitri Samovski, Gemma Fraterrigo, Adewole L. Okunade,
Bruce W. Patterson and Samuel Klein
Center for Human Nutrition and Atkins Center of Excellence in Obesity
Medicine, Washington University School of Medicine, St. Louis, Missouri,
USA.
Address correspondence to: Samuel Klein, Center for Human Nutrition,
Washington University School of Medicine, 660 South Euclid Avenue, Campus
Box 8031, St. Louis, Missouri 63110, USA. Phone: 314.362.8708; E-mail:
[log in to unmask]
Published January 2, 2015
Submitted: August 7, 2014; Accepted: November 20, 2014.
The Journal of Clinical Investigation
http://www.jci.org/articles/view/78425
BACKGROUND. Obesity is associated with insulin resistance and increased
intrahepatic triglyceride (IHTG) content, both of which are key risk
factors for diabetes and cardiovascular disease. However, a subset of
obese people does not develop these metabolic complications. Here, we
tested the hypothesis that people defined by IHTG content and insulin
sensitivity as metabolically normal obese (MNO), but not those defined as
metabolically abnormal obese (MAO), are protected from the adverse
metabolic effects of weight gain.
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RESULTS. Although the increase in body weight and fat mass was the same in
both groups, hepatic, skeletal muscle, and adipose tissue insulin
sensitivity deteriorated, and VLDL apoB100 concentrations and secretion
rates increased in MAO, but not MNO, subjects. Moreover, biological
pathways and genes associated with adipose tissue lipogenesis increased in
MNO, but not MAO, subjects.
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CONCLUSIONS. These data demonstrate that MNO people are resistant, whereas
MAO people are predisposed, to the adverse metabolic effects of moderate
weight gain and that increased adipose tissue capacity for lipogenesis
might help protect MNO people from weight gaininduced metabolic
dysfunction.
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The Full Text of this journal article appears to be available at no cost
at the website link immediately above.
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Sincerely,
David Dillard
Temple University
(215) 204 - 4584
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