Greetings,
Regarding the VBM8 toolbox -- I have typically been running VBM8 on native space anatomical images to generate a skull-stripped PVE image that has been rigid-body registered into MNI space. I've found this to give me the best template to coregister my functional images to prior to preprocessing and subsequent normalization.
I notice that I need to feed the PVE image back into the toolbox to generate appropriate deformation fields, which raises a question about the order of preprocessing steps employed by the toolbox. By not making sure the anatomical images are in MNI space (i.e., with AC at 0,0,0) when I first enter them into the toolbox, am I generating incorrect deformation fields/jacobian determinants? If so, has modulation been compromised?
All the best, and thanks in advance,
Patrick
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