Dear Felix,
I now, of course. The molecule on the picture look like consisting of
rather light atoms, and I would be very impressed if the instrumentation
and software at that time allowed the reliable detection of the hand
from that particular molecule.
I don't assume Dorothy Hodgkin made a mistake leading to that note but
rather realised of what was available to her and made the best of it
(which was clearly very outstanding). But of course I may be wrong and I
am happy to learn.
Best,
Tim
On 05/13/2014 10:12 AM, Felix Frolow wrote:
> Anomalous signal analysis is quite early development in structural biology. There are couple of classical papers by Bijvoet in
> the first issues oaf Acta Crystallographica. Presently I am out of ability to find exact references :-/
> Dr Felix Frolow
> Professor of Structural Biology and Biotechnology, Department of Molecular Microbiology and Biotechnology
> Tel Aviv University 69978, Israel
>
> Acta Crystallographica F, co-editor
>
> e-mail: [log in to unmask]
> Tel: ++972-3640-8723
> Fax: ++972-3640-9407
> Cellular: 0547 459 608
>
> On May 13, 2014, at 10:38 , Tim Gruene <[log in to unmask]> wrote:
>
>> Dear Javier,
>>
>> without the analysis of the anomalous signal you have a 50:50 chance to
>> get the correct configuration, and those times were too early for that.
>> The comment may have been added later and/or from using a different type
>> of experiment.
>>
>> Best,
>> Tim
>>
>> On 05/13/2014 02:21 AM, Javier Gonzalez wrote:
>>> Interestingly, that molecule has the opposite configuration. The actual
>>> model<http://upload.wikimedia.org/wikipedia/commons/6/6e/Molecular_model_of_Penicillin_by_Dorothy_Hodgkin_%289663803982%29.jpg>has
>>> a posting saying "(wrong absolute configuration)".
>>> I wonder what's the story behind it...
>>>
>>>
>>>
>>>
>>> On Mon, May 12, 2014 at 2:28 PM, Gregg Crichlow <[log in to unmask]>wrote:
>>>
>>>> Actually, it was noticing penG that made me mouse over it myself. After
>>>> spending many years completing a thesis on beta-lactamases, I was very
>>>> surprised - and excited - to see that on something as main-stream as
>>>> Google. But then when I paid attention more closely, I saw that they even
>>>> have a good representation of the electron density in three orthogonal
>>>> planes surrounding the molecule! Dr. James Knox (my thesis advisor) just
>>>> informed me that the density maps are on exhibit at the British Museum of
>>>> Science.
>>>> I have heard so much about Dorothy Hodgkin from my thesis advisor,
>>>> that I became very familiar with her name and legacy, although I never had
>>>> met her.
>>>>
>>>> Gregg
>>>>
>>>>
>>>> On Mon, May 12, 2014 at 9:39 AM, Robert Sweet <[log in to unmask]> wrote:
>>>>
>>>>> Check out google.com. They're announcing what would have been Dorothy
>>>>> Hodgkin's 104th b-day. I saw the molecule, and said to myself, "My
>>>>> goodness, that's penicillin G," and the mouseover announced the big day.
>>>>>
>>>>> She was a great scientist and a friend to thousands of us.
>>>>>
>>>>> Bob
>>>>>
>>>>> =========================================================================
>>>>> Robert M. Sweet E-Dress: [log in to unmask]
>>>>> Group Leader, PXRR: Macromolecular ^ (that's L
>>>>> Crystallography Research Resource at NSLS not 1)
>>>>> http://px.nsls.bnl.gov/
>>>>> Photon Sciences and Biosciences Dept
>>>>> Office and mail, Bldg 745, a.k.a. LOB-5
>>>>> Brookhaven Nat'l Lab. Phones:
>>>>> Upton, NY 11973 631 344 3401 (Office)
>>>>> U.S.A. 631 344 2741 (Facsimile)
>>>>> =========================================================================
>>>>>
>>>>
>>>>
>>>
>>>
>>
>> --
>> Dr Tim Gruene
>> Institut fuer anorganische Chemie
>> Tammannstr. 4
>> D-37077 Goettingen
>>
>> GPG Key ID = A46BEE1A
>>
>
>
--
Dr Tim Gruene
Institut fuer anorganische Chemie
Tammannstr. 4
D-37077 Goettingen
GPG Key ID = A46BEE1A
|
