Dear experts,
I'd like to find out how well it works to take my skeletonised FA images from after TBSS through to a VBM-style analysis in SPM. I'm sure you will all tell me to use FSL for the statistics... but please indulge me for a moment (since I'm attempting to compare against some results I already have in SPM).
Firstly I believe these FA skeletons will be in MNI space, since I aligned them to the FMRIB58_FA template during TBSS? At least they appear to be in the correct space when I use check reg in spm.
Secondly, due to the high resolution and lack of smoothing of these images, is it appropriate to smooth the skeletons (perhaps by just a small kernel, e.g. 4mm) prior to performing the SPM group analysis?
I appreciate your advice, especially concerning any problems with this that I may not have anticipated.
Antoinette
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