Dear Jesper,
sorry for not explaining in more detail. We are doing research on brain elastography and use a motion-encoding EPI-sequence. The question I had was, whether topup can also be used to remove / reduce the distortions, which can also be found in the phase data. Since the phase data is between -Pi and +Pi, I'm not sure if this works or if influences subsequent phase unwrapping.
We already tried to optimize our acquisition strategy (low TE, iPAT). For further detail on the technique we are using you can find a similar project from Berlin here: http://www.ncbi.nlm.nih.gov/pubmed/24368262
Best,
Martin
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