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MEDICAL: PHARMACY PHARMACEUTICAL PHARMACOLOGY: DRUG :
MEDICAL: CHOLESTEROL:
Drug Cuts Cholesterol Beyond What Statins Can Do?
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Drug Cuts Cholesterol Beyond What Statins Can Do?
Whether it also prevents heart attacks and strokes isn't known yet,
experts say
WebMD News from HealthDay
By Steven Reinberg
HealthDay Reporter
http://www.webmd.com/cholesterol-management/news/20140330/
new-drug-lowers-cholesterol-beyond-what-statins-can-do-study-finds
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A shorter URL for the above link:
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http://tinyurl.com/ovkfp8y
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SUNDAY, March 30, 2014 (HealthDay News) -- Two studies find that an
experimental cholesterol-lowering drug is effective when combined with
statins and beats another add-on drug when it comes to helping
hard-to-treat patients.
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The drug, evolocumab, is an injectable antibody that works differently
than statins by increasing the ability of the liver to clear LDL ("bad")
cholesterol from the blood. The value of this drug is that it lowers
cholesterol in patients who cannot tolerate statins or for whom statins
don't lower cholesterol enough.
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"These two new studies provide further evidence of the efficacy of
evolocumab for lowering LDL cholesterol in statin-treated and in
statin-intolerant patients. The results are impressive," said Dr. Gregg
Fonarow, a professor of medicine at the University of California, Los
Angeles, who had no part in either study.
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Both studies were funded by Amgen, the maker of evolocumab, and the
results were scheduled to be presented Sunday at the American College of
Cardiology's annual meeting, in Washington, D.C.
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"Evolocumab may provide an effective option for patients needing
additional LDL-cholesterol lowering," said Dr. Jennifer Robinson, director
of the Prevention Intervention Center at the University of Iowa College of
Public Health, and lead author of the first study.
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In that trial, evolocumab was added to statins such as atorvastatin
(Lipitor), rosuvastatin (Crestor) and simvastatin (Zocor). The trial,
which involved almost 1,900 patients, also compared the effectiveness of
evolucumab when pitted against ezetimibe (Zetia), another drug that can be
added to statin therapy to further reduce cholesterol.
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"Evolocumab further reduces LDL cholesterol by about 65 to 75 percent when
added to a statin. Evolocumab reduces LDL cholesterol more than ezetimibe
-- about a 15 to 20 percent additional LDL-cholesterol reduction, when
added to statin," Robinson said.
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The complete article may be read at the URL above.
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