Hi,
Demean the patient numbers on their own and then include zeros for the controls (as there is no useful information for the controls). This is a fairly standard thing to do for disease scores.
All the best,
Mark
On 9 Jan 2014, at 16:14, Hamzah Hamid Baagil <[log in to unmask]> wrote:
> Hi Mark,
> Do I need to include the UPDRS of the control group since they are all zero or only from the patients to demeaned the covariate?
>
>
> Thank you for your help!
> Hamzah
>
> ----- Ursprüngliche Nachricht -----
> Von: Mark Jenkinson <[log in to unmask]>
> Datum: Donnerstag, 9. Januar 2014, 11:02
> Betreff: Re: [FSL] TBSS patients vs control with covariate
> An: [log in to unmask]
>
> > Hi,
> >
> > This is generally correct but you should demean your covariate
> > scores before putting them into the design matrix.
> > See: http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/GLM#Two-
> > Group_Difference_Adjusted_for_Covariate
> > All the best,
> > Mark
> >
> >
> > On 8 Jan 2014, at 13:07, Hamzah Baagil
> > <[log in to unmask]> wrote:
> >
> > > Dear FSLexperts,
> > >
> > > I would like to compare patients vs controls in TBSS analysis
> > including the covariate UPDRS score. However I am not sure if my
> > design contrast and matrix is correct, which looks like this
> > >
> > > /ContrastName1 Controls > Patients
> > > /ContrastName2 Patients > Controls
> > > /ContrastName3 UPDRS
> > > /NumWaves 3
> > > /NumContrasts 3
> > >
> > /PPheights 1.092957e+00 1.092957e+00 4.000000e+01> /RequiredEffect 2.849 2.849 3.235
> > >
> > > /Matrix
> > > 1.000000e+00 -1.000000e+00 0.000000e+00
> > > -1.000000e+00 1.000000e+00 0.000000e+00
> > > 0.000000e+00 0.000000e+00 1.000000e+00
> > >
> > hbaagil@u1:/daten/kfo/KFO_group/Hamzah/TBSS_projects/Projekt_arbeit/fsl-5.0.4/tbss2_reg-T/patients_vs_subjects_covariate_UPDRS_P_5000/stats$ more design.mat
> > > /NumWaves 3
> > > /NumPoints 46
> > >
> > /PPheights 1.000000e+00 1.000000e+00 5.100000e+01>
> > > /Matrix
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 1.000000e+00 0.000000e+00 0.000000e+00
> > > 0.000000e+00 1.000000e+00 3.100000e+01
> > > 0.000000e+00 1.000000e+00 4.500000e+01
> > > 0.000000e+00 1.000000e+00 1.800000e+01
> > > 0.000000e+00 1.000000e+00 2.400000e+01
> > > 0.000000e+00 1.000000e+00 4.500000e+01
> > > 0.000000e+00 1.000000e+00 1.100000e+01
> > > 0.000000e+00 1.000000e+00 1.900000e+01
> > > 0.000000e+00 1.000000e+00 1.700000e+01
> > > 0.000000e+00 1.000000e+00 1.500000e+01
> > > 0.000000e+00 1.000000e+00 5.100000e+01
> > > 0.000000e+00 1.000000e+00 2.200000e+01
> > > 0.000000e+00 1.000000e+00 2.600000e+01
> > > 0.000000e+00 1.000000e+00 2.500000e+01
> > > 0.000000e+00 1.000000e+00 2.500000e+01
> > > 0.000000e+00 1.000000e+00 2.500000e+01
> > > 0.000000e+00 1.000000e+00 2.800000e+01
> > > 0.000000e+00 1.000000e+00 4.000000e+01
> > > 0.000000e+00 1.000000e+00 4.500000e+01
> > > 0.000000e+00 1.000000e+00 2.000000e+01
> > > 0.000000e+00 1.000000e+00 3.700000e+01
> > > 0.000000e+00 1.000000e+00 2.900000e+01
> > > 0.000000e+00 1.000000e+00 3.600000e+01
> > > 0.000000e+00 1.000000e+00 1.900000e+01
> > >
> > > I would appreciate any help.
> > >
> > > Thank you,
> > > Hamzah
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