Dear Shane,
To add a bit of detail to Frank von Delft's suggestion, perhaps the best example is the structure of the yeast F1-ATPase that has 3 copies in the asu, from David Mueller's lab in Chicago. Two of these are very similar, but the third is rather different and shows a (physiologically relevant) phosphate binding site that is not found in the other two copies. I would not describe the differences as dramatic though.
The paper is: Kabaleeswaran et al., EMBO J 25, 5433 (2006)
PDB ID 2HLD
Best wishes,
Andrew Leslie
On 27 Jan 2014, at 18:08, Shane Caldwell <[log in to unmask]> wrote:
> Hi ccp4bb,
>
> I'm putting together a talk for some peers that highlights strengths and weaknesses of structural models for the outsider. For one point, I'd like to find some examples of proteins that show very different conformations between different copies in the ASU. One example I know of is c-Abl (1OPL), which crystallizes with both autoinhibited and active forms in the ASU, with dramatically different domain organization. I'd like to find some additional examples - can anyone suggest some other structures that have multiple copies with large structural variations?
>
> Thanks in advance!
>
> Shane Caldwell
> McGill University
>
>
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