Yes, indeed Andrey.
And this results from resonance (tautomerization) of the guanidinium group.
Regards,
Nadir Mrabet
Pr. Nadir T. Mrabet
Structural & Molecular Biochemistry
N-gere - INSERM U-954
University of Lorraine, Nancy
School of Sciences and Technologies
& School of Medicine
9, Avenue de la Foret de Haye, BP 184
54505 Vandoeuvre-les-Nancy Cedex
France
Phone: +33 (0)3.83.68.32.73
Fax: +33 (0)3.83.68.32.79
E-mail: Nadir.Mrabet <at> univ-lorraine.fr
On 08/10/2013 18:01, Andrey Feklistov wrote:
> Hi Jan,
>
> please note, Arg-Arg proximity is not always repulsive: guanidinium groups can associate bridged by H-bonds and interactions with water molecules or neighboring amino acids. There are many examples of these unusual Arg formations, see for reference:
>
> Neves, Yeager and Abagyan (2012) "Unusual Arginine Formations in Protein Function and Assembly: Rings, Strings and Stacks", J. Phys. Chem. B 116, 7006−7013
>
> Hope this is helpful,
>
> Andrey
>
|