Hi Theresa,
Per your question about determination of membrane proteins - solution NMR is quite capable of delivering structures of proteins in the presence of detergents, such as the KcsA channel (see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242490/). You should note, though, that many membrane proteins are helical, and these proteins are notoriously difficult to determine via NMR (see this article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862971/). Even so, if it won't crystallize, and you want it really bad, then go for it!
Chen
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