My work with colicin M class bacteriocins shows that they require Ca2+ (or Mg or Mn) for catalysis:
1 Grinter, R., Roszak, A. W., Cogdell, R. J., Milner, J. J. and Walker, D. (2012) The Crystal Structure of the Lipid II-degrading Bacteriocin Syringacin M Suggests Unexpected Evolutionary Relationships between Colicin M-like Bacteriocins. J. Biol. Chem. 287, 38876-38888
Best Regards,
Rhys
________________________________________
From: CCP4 bulletin board [[log in to unmask]] On Behalf Of Wei Liu [[log in to unmask]]
Sent: 31 May 2013 11:25
To: [log in to unmask]
Subject: [ccp4bb] Calcium ions in enzymes
Dear all,
As we all know, many proteins contain calcium ions. Does anyone know if there are reported cases where calcium ions play a catalytic role rather than a structural role in enzymes?
Best
Wei Liu
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