Dear SPMers;
I am running a case report which I would like to mapping the brain activation of one volunteer who took an hallucinogenic substance common in some regions here in Brazil. We acquired two SPECT images from this volunteer; one day before he/she had taken the substance (SPECT-PRE) and another one after he/she taken the substance (SPECT-POS).
For the SPM analysis we ran two analysis:
1) We compared the SPECT-PRE versus 10 SPECT controls (using two sample T-Test).
2) We compared the SPECT-POS versus 10 SPECT controls (using two sample T-Test).
In an previous SPM manual I found:
->Compare-populations: 1 condition, 1 scan/condition (=modality-adjusted two-sample ttest), e.g., a PET or SPECT ligand study comparing patients to normal controls.
My question is: Is the two sample T-Test appropriate for this kind of analysis? Which model is the most appropriate for that?
|