Dear FSL team,
I am trying to run the TBSS analysis on mice FA data. My problem is that
I have in vivo scans with non-isotropic 0.3*0.15*0.6mm voxels. At this
resolution, some upsampling of the images was necessary to get the
tbss_skeleton script to build a skeleton with reasonable similarity to
the underlying anatomy. (I've compared it to what Ruest et al. published
in 2011 in NMR in biomedicine using high-res isotropic data).
My question is: how will upsampling affect the statistical results?. I
am comparing wild-type to knock-out mice (2 groups unpaired t-test).
I have been through the Smith & Nichols Neuroimage paper on TFCE and I
understand that if the extension of the significant clusters to be fed
into the TFCE algorithm is given in # of vxls, then upsampling will
influence the output, whereas if it is given in mm3 it won't (that much?).
Can somebody give me some help with this?
Thanks a lot in advance,
Alberto
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Alberto Corcoba
Centre d'Imagerie BioMédicale
EPFL - LIFMET
Station 6
1015 Lausanne, Switzerland
+41 (0) 21 69 30586
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