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SPORTS MEDICINE :
PHYSICAL EXERCISE AND FITNESS :
MEDICAL: CONDITIONS: OBESITY:
Obesity, Aerobic Exercise, and Vascular Disease: The Role of Oxidant
Stress
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Fenster, C. P., Weinsier, R. L., Darley?Usmar, V. M., & Patel, R. P.
(2012).
Obesity, aerobic exercise, and vascular disease: the role of oxidant
stress.
Obesity research, 10(9), 964-968.
Obesity Research
Volume 10, Issue 9, pages 964-968, September 2002
http://onlinelibrary.wiley.com/doi/10.1038/oby.2002.131/full
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Keywords:
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physical activity;exercise;reactive oxygen species;nitric
oxide;atherosclerosis
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Abstract
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Oxidant formation in the vasculature contributes to vascular disease and
dysfunction associated with obesity. In contrast, exercise-dependent
production of oxidants may stimulate adaptive responses that protect
against the development of such diseases. In this review, we discuss
current concepts in the biology of reactive oxygen and nitrogen species
and how their function is modulated in the context of vascular disease,
obesity, and aerobic exercise.
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Article Topics Covered
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Introduction
Oxidant Stress and ROS/RNS
Role of ROS/RNS in Vascular Function
Oxidant Stress and Obesity
Role of ROS/RNS in Atherosclerosis
Role of ROS/RNS in Diabetes and Hypertension
ROS/RNS and Aerobic Exercise
Conclusions
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Emerging evidence suggests that changes in oxidant formation are evident
in obesity and that body-fat reduction (for obese individuals) may reduce
oxidant formation and, in turn, impact vascular redox signaling.
This has important health implications because ROS/RNS is believed to play
a central role in the development of atherosclerosis and to contribute to
obesity-related diseases such as hypertension and diabetes. Additional
health benefits may be achieved with regular exercise because exercise
can induce adaptations that increase NO bioactivity and minimize oxidative
injury.
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The complete article may be read at the URL above.
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