Your null hypothesis is that there is the change in fMRI signal is not
correlated to the change in clinical score.
The easiest way to do this is to create a difference image for pre-
and post- score for each subject and then use a one-sample t-test of
these images with the change in clinical score as a regressor.
Best Regards, Donald McLaren
=================
D.G. McLaren, Ph.D.
Research Fellow, Department of Neurology, Massachusetts General Hospital and
Harvard Medical School
Postdoctoral Research Fellow, GRECC, Bedford VA
Website: http://www.martinos.org/~mclaren
Office: (773) 406-2464
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On Tue, Nov 20, 2012 at 10:51 AM, Hongyu Yang <[log in to unmask]> wrote:
> Hello List,
>
> I have a correlation analysis question, and did not find similar discussions
> in the list.
> We finished two scans with same fMRI task for our patients before and after
> 2 months medication, want to
> see if there were some correlations between clinical symptom changes and
> brain response
> changes. We have finished all the basic analysis for the subjects, including
> pre and post data.
> How can we get the contrast image of pre and post for one same regressor?
> I tried to use all the design in the SPM, like paired-t-test, one way ANOVA
> (within subject),
> full factial, and flexible factorial. I did not find they can provide the
> contrasts image of pre and post data.
> At last, I think maybe I need to combine the two pre and post data into one
> basic analysis, as session 1 and 2,
> and then I can compare them as I choose. After this I can do my correlation
> analysis between clinical
> improvements and brain response changes. But I am not sure if my thought is
> correct, so I ask you, SPM professionals to confirm.
>
>
> Thanks,
>
> Hongyu Yang, PhD
> Research Specialist in Health Science
> Pediatric Brain Research And InterventioN Center
> Department of Psychiatry
> 1747 West Roosevelt Road, M/C 747
> Chicago, Illinois 60608
> Phone: (312) 413-4622
> Fax: (312) 413-0063
> Email: [log in to unmask]
> http://www.psych.uic.edu/brain-center
>
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