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ACS Congratulates the 2012 Nobel Prize in Chemistry Winners
[Ordinary Items. Extraordinary Results.]<http://c.acs.org/cyatb/511866/0/208052/20363/0/D/0/0/xivv.html>
ACS Congratulates the 2012 Nobel Prize in Chemistry Winners
ACS Publications congratulates long time authors Robert J. Lefkowitz and Brian K. Kobilka on winning the 2012 Nobel Prize in Chemistry for their studies of G-protein-coupled receptors (GPCRs). These receptors allow cells in the body to sense and respond to outside signals and are the target for several commonly prescribed prescription drugs including beta blockers, antihistamines and antidepressants.
ACS Publications also congratulates Accounts of Chemical Research author David Wineland<http://c.acs.org/cyatb/511866/0/208052/20322/0/D/0/0/xivv.html>, on the 2012 Nobel Prize in Physics and Crystal Growth & Design author Shinya Yamanaka<http://c.acs.org/cyatb/511866/0/208052/20323/0/D/0/0/xivv.html> on the 2012 Nobel Prize in Physiology or Medicine.
View their research from ACS journals free for a limited time.
1975-1980 / 1981-1985 / 1986-1990 / 1991-1995 / 1996-1999 / 2002-Current
2002-Current
Conformational Dynamics of Single G Protein-Coupled Receptors in Solution <http://c.acs.org/cyatb/511866/0/208052/20324/0/D/0/0/xivv.html>
Samuel Bockenhauer, Alexandre Fürstenberg, Xiao Jie Yao, Brian K. Kobilka, and W. E. Moerner
The Journal of Physical Chemistry B 2011
DOI: 10.1021/jp204843r<http://c.acs.org/cyatb/511866/0/208052/20324/0/D/0/0/xivv.html>
Tandem Facial Amphiphiles for Membrane Protein Stabilization <http://c.acs.org/cyatb/511866/0/208052/20325/0/D/0/0/xivv.html>
Pil Seok Chae, Kamil Gotfryd, Jennifer Pacyna, Larry J. W. Miercke, Søren G. F. Rasmussen, Rebecca A. Robbins, Rohini R. Rana, Claus J. Loland, Brian Kobilka, Robert Stroud, Bernadette Byrne, Ulrik Gether, and Samuel H. Gellman
Journal of the American Chemical Society 2010
DOI: 10.1021/ja1072959<http://c.acs.org/cyatb/511866/0/208052/20325/0/D/0/0/xivv.html>
Mass Spectrometric Analysis of Agonist Effects on Posttranslational Modifications of the β2-Adrenoceptor in Mammalian Cells<http://c.acs.org/cyatb/511866/0/208052/20365/0/D/0/0/xivv.html>
Michelle Trester-Zedlitz, Al Burlingame, Brian Kobilka, and Mark von Zastrow
Biochemistry 2005
DOI: 10.1021/bi0475469<http://c.acs.org/cyatb/511866/0/208052/20365/0/D/0/0/xivv.html>
Plasmon-Waveguide Resonance Studies of Ligand Binding to the Human β2-Adrenergic Receptor <http://c.acs.org/cyatb/511866/0/208052/20328/0/D/0/0/xivv.html>
Savitha Devanathan, Zhiping Yao , Zdzislaw Salamon, Brian Kobilka, and Gordon Tollin
Biochemistry 2004
DOI: 10.1021/bi035825a<http://c.acs.org/cyatb/511866/0/208052/20328/0/D/0/0/xivv.html>
β2-Adrenergic Receptor Stimulated, G Protein-Coupled Receptor Kinase 2 Mediated, Phosphorylation of Ribosomal Protein P2 <http://c.acs.org/cyatb/511866/0/208052/20329/0/D/0/0/xivv.html>
Jennifer L. R. Freeman, Philippe Gonzalo, Julie A. Pitcher, Audrey Claing, Jean-Pierre Lavergne, Jean-Paul Reboud, and Robert J. Lefkowitz
Biochemistry 2002
DOI: 10.1021/bi020145d<http://c.acs.org/cyatb/511866/0/208052/20329/0/D/0/0/xivv.html>
Phosphorylation of β-Arrestin2 Regulates Its Function in Internalization of β2-Adrenergic Receptors <http://c.acs.org/cyatb/511866/0/208052/20330/0/D/0/0/xivv.html>
Fang-Tsyr Lin, Wei Chen, Sudha Shenoy, Mei Cong, Sabrina T. Exum, and Robert J. Lefkowitz
Biochemistry 2002
DOI: 10.1021/bi025705n<http://c.acs.org/cyatb/511866/0/208052/20330/0/D/0/0/xivv.html>
Analysis of Biomolecular Interactions Using a Miniaturized Surface Plasmon Resonance Sensor <http://c.acs.org/cyatb/511866/0/208052/20331/0/D/0/0/xivv.html>
Rebecca J. Whelan, Thorsten Wohland, Lars Neumann, Bo Huang, Brian K. Kobilka and Richard N. Zare
Analytical Chemistry 2002
DOI: 10.1021/ac025669y<http://c.acs.org/cyatb/511866/0/208052/20331/0/D/0/0/xivv.html>
1996-1999
Restricting the Mobility of Gsα: Impact on Receptor and Effector Coupling <http://c.acs.org/cyatb/511866/0/208052/20332/0/D/0/0/xivv.html>
Tae Weon Lee, Roland Seifert, Xiaoming Guan, and Brian K. Kobilka
Biochemistry 1999
DOI: 10.1021/ac025669y<http://c.acs.org/cyatb/511866/0/208052/20332/0/D/0/0/xivv.html>
Palmitoylation Increases the Kinase Activity of the G Protein-Coupled Receptor Kinase, GRK6<http://c.acs.org/cyatb/511866/0/208052/20333/0/D/0/0/xivv.html>
Robert H. Stoffel, James Inglese, Alexander D. Macrae, Robert J. Lefkowitz and Richard T. Premont
Biochemistry 1998
DOI: 10.1021/bi981432d<http://c.acs.org/cyatb/511866/0/208052/20333/0/D/0/0/xivv.html>
Ligand Stabilization of the β2 Adrenergic Receptor: Effect of DTT on Receptor Conformation Monitored by Circular Dichroism and Fluorescence Spectroscopy <http://c.acs.org/cyatb/511866/0/208052/20334/0/D/0/0/xivv.html>
Sansan Lin, Ulrik Gether, and Brian K. Kobilka
Biochemistry 1996
DOI: 10.1021/bi961619+<http://c.acs.org/cyatb/511866/0/208052/20334/0/D/0/0/xivv.html>
Ras-Dependent Activation of Fibroblast Mitogen-Activated Protein Kinase by 5-HT1A Receptor via a G Protein βγ-Subunit-Initiated Pathway <http://c.acs.org/cyatb/511866/0/208052/20335/0/D/0/0/xivv.html>
Maria N. Garnovskaya, Tim van Biesen, Brian Hawes, Shirley Casañas Ramos, Robert J. Lefkowitz and John R. Raymond
Biochemistry 1996
DOI: 10.1021/bi961764n<http://c.acs.org/cyatb/511866/0/208052/20335/0/D/0/0/xivv.html>
Members of the G Protein-Coupled Receptor Kinase Family That Phosphorylate the β2-Adrenergic Receptor Facilitate Sequestration <http://c.acs.org/cyatb/511866/0/208052/20336/0/D/0/0/xivv.html>
Luc Ménard, Stephen S. G. Ferguson, Larry S. Barak, Lucie Bertrand, Richard T. Premont, Anne-Marie Colapietro, Robert J. Lefkowitz and Marc G. Caron
Biochemistry 1998
DOI: 10.1021/bi952961+<http://c.acs.org/cyatb/511866/0/208052/20336/0/D/0/0/xivv.html>
1991-1995
Desensitization of the Isolated β2-Adrenergic Receptor by β-Adrenergic Receptor Kinase,cAMP-Dependent Protein Kinase, and Protein Kinase C Occurs via Distinct Molecular Mechanisms <http://c.acs.org/cyatb/511866/0/208052/20337/0/D/0/0/xivv.html>
Julie Pitcher, Martin J. Lohse, Juan Codina,Marc G. Caron, and Robert J. Lefkowitz
Biochemistry 1992
DOI: 10.1021/bi00127a021<http://c.acs.org/cyatb/511866/0/208052/20337/0/D/0/0/xivv.html>
Role of Acidic Amino Acids in Peptide Substrates of the β-Adrenergic Receptor Kinase and Rhodopsin Kinase <http://c.acs.org/cyatb/511866/0/208052/20338/0/D/0/0/xivv.html>
James J. Onorato, Krzysztof Palczewski, John W. Regan, Marc G. Caron, Robert J. Lefkowitz, and Jeffrey L. Benovic
Biochemistry 1991
DOI: 10.1021/bi00235a002<http://c.acs.org/cyatb/511866/0/208052/20338/0/D/0/0/xivv.html>
Functional Interactions of Recombinant α2 Adrenergic Receptor Subtypes and G Proteins in Reconstituted Phospholipid Vesicles <http://c.acs.org/cyatb/511866/0/208052/20364/0/D/0/0/xivv.html>
Hitoshi Kurose, John W. Regan, Marc G. Caron,and Robert J. Lefkowitz
Biochemistry 1991
DOI: 10.1021/bi00227a024<http://c.acs.org/cyatb/511866/0/208052/20364/0/D/0/0/xivv.html>
1986-1990
Role of Extracellular Disulfide-Bonded Cysteines in the Ligand Binding Function of the β2-Adrenergic Receptor <http://c.acs.org/cyatb/511866/0/208052/20340/0/D/0/0/xivv.html>
Henrik G. Dohlman, Marc G. Caron, Antonio DeBlasi, Thomas Frielle, and Robert J. Lefkowitz
Biochemistry 1990
DOI: 10.1021/bi00461a018<http://c.acs.org/cyatb/511866/0/208052/20340/0/D/0/0/xivv.html>
Localization of the Fourth Membrane spanning Domain as a Ligand Binding Site in the Human Platelet α2-Adrenergic Receptor <http://c.acs.org/cyatb/511866/0/208052/20341/0/D/0/0/xivv.html>
Hiroaki Matsui, Robert J. Lefkowitz, Marc G. Caron, and John W. Regan
Biochemistry 1989
DOI: 10.1021/bi00435a075<http://c.acs.org/cyatb/511866/0/208052/20341/0/D/0/0/xivv.html>
Phosphorylation of Chick Heart Muscarinic Cholinergic Receptors by the β-Adrenergic Receptor Kinase <http://c.acs.org/cyatb/511866/0/208052/20342/0/D/0/0/xivv.html>
Madan M. Kwatra, Jeffrey L. Benovic, Marc G. Caron, Robert J. Lefkowitz, and M. Marlene Hosey
Biochemistry 1989
DOI: 10.1021/bi00437a005<http://c.acs.org/cyatb/511866/0/208052/20342/0/D/0/0/xivv.html>
Identification and Sequence of a Binding Site Peptide of the β2-Adrenergic Receptor <http://c.acs.org/cyatb/511866/0/208052/20343/0/D/0/0/xivv.html>
Henrik G. Dohlman, Marc G. Caron, Catherine D. Strader, Nourdine Amlaiky, and Robert J. Lefkowitz
Biochemistry 1988
DOI: 10.1021/bi00406a002<http://c.acs.org/cyatb/511866/0/208052/20343/0/D/0/0/xivv.html>
A Family of Receptors Coupled to Guanine Nucleotide Regulatory Proteins <http://c.acs.org/cyatb/511866/0/208052/20344/0/D/0/0/xivv.html>
Henrik G. Dohlman, Marc G. Caron, and Robert J. Lefkowitz
Biochemistry 1987
DOI: 10.1021/bi00384a001<http://c.acs.org/cyatb/511866/0/208052/20344/0/D/0/0/xivv.html>
Functional Differences in the βγ Complexes of Transducin and the Inhibitory Guanine Nucleotide Regulatory Protein <http://c.acs.org/cyatb/511866/0/208052/20345/0/D/0/0/xivv.html>
Richard A. Cerione, Peter Gierschik, Claudia Stanizsewski, Jeffrey L. Benovic, Juan Codina, Robert Somers, Lutz Birnbaumer, Allen M. Spiegel, Robert J. Lefkowitz, and Marc G. Caron
Biochemistry 1987
DOI: 10.1021/bi00379a041<http://c.acs.org/cyatb/511866/0/208052/20345/0/D/0/0/xivv.html>
A Novel Catecholamine-Activated Adenosine Cyclic 3',5'-Phosphate Independent Pathway for β-Adrenergic Receptor Phosphorylation in Wild-Type and Mutant S49 Lymphoma Cells: Mechanism of Homologous Desensitization of Adenylate Cyclase <http://c.acs.org/cyatb/511866/0/208052/20346/0/D/0/0/xivv.html>
Ruth H. Strasser, David R. Sibley, and Robert J. Lefkowitz
Biochemistry 1986
DOI: 10.1021/bi00354a027<http://c.acs.org/cyatb/511866/0/208052/20346/0/D/0/0/xivv.html>
1981-1985
Transducin and the Inhibitory Nucleotide Regulatory Protein Inhibit the Stimulatory Nucleotide Regulatory Protein Mediated Stimulation of Adenylate Cyclase in Pospholipid Vesicle Systems <http://c.acs.org/cyatb/511866/0/208052/20347/0/D/0/0/xivv.html>
Richard A. Cerione, Juan Codina, Brian F. Kilpatrick, Claudia Staniszewski, Peter Gierschik, Robert L. Somers, Allen M. Spiegel, Lutz Birnbaumer, Marc G. Caron, and Robert J. Lefkowitz
Biochemistry 1985
DOI: 10.1021/bi00338a002<http://c.acs.org/cyatb/511866/0/208052/20347/0/D/0/0/xivv.html>
The Mammalian β2-Adrenergic Receptor: Reconstitution of Functional Interactions Between Pure Receptor and Pure Stimulatory Nucleotide Binding Protein of the Adenylate Cyclase System <http://c.acs.org/cyatb/511866/0/208052/20348/0/D/0/0/xivv.html>
Hiroaki Matsui, Robert J. Lefkowitz, Marc G. Caron, and John W. Regan
Biochemistry 1984
DOI: 10.1021/bi00315a003<http://c.acs.org/cyatb/511866/0/208052/20348/0/D/0/0/xivv.html>
The Mammalian β2-Adrenergic Receptor: Purification and Characterization <http://c.acs.org/cyatb/511866/0/208052/20349/0/D/0/0/xivv.html>
Jeffrey L. Benovic, Robert G. L. Shorr, Marc G. Caron, and Robert J. Lefkowitz
Biochemistry 1984
DOI: 10.1021/bi00315a002<http://c.acs.org/cyatb/511866/0/208052/20349/0/D/0/0/xivv.html>
Determination of the Molecular Size of Frog and Turkey Erythrocyte β-Adrenergic Receptors by Radiation Inactivation <http://c.acs.org/cyatb/511866/0/208052/20350/0/D/0/0/xivv.html>
Robert G. L. Shorr, Ellis S. Kempner, Mark W. Strohsacker, Ponnal Nambi, Robert J. Lefkowitz, and Marc G. Caron
Biochemistry 1984
DOI: 10.1021/bi00299a025<http://c.acs.org/cyatb/511866/0/208052/20350/0/D/0/0/xivv.html>
Synthesis of Iodine-125 labeled (+-)-15-(4-Azidobenzyl)carazolol: A Potent β-Adrenergic Photoaffinity Probe <http://c.acs.org/cyatb/511866/0/208052/20351/0/D/0/0/xivv.html>
Sarah L. Heald, Peter W. Jeffs, Thomas N. Lavin, Ponnal Nambi, Robert J. Lefkowitz, and Marc G. Caron
Journal of Medicinal Chemistry 1983
DOI: 10.1021/jm00360a009<http://c.acs.org/cyatb/511866/0/208052/20351/0/D/0/0/xivv.html>
1975-1980
Parallel Modulation of Catecholamineactivation of Adenylate Cyclase and Formation of the High-Affinity Agonist Receptor Complex in Turkey Erythrocyte Membranes by Temperature and cis-Vaccenic Acid <http://c.acs.org/cyatb/511866/0/208052/20352/0/D/0/0/xivv.html>
Margaret M. Briggs and Robert J. Lefkowitz
Biochemistry 1980
DOI: 10.1021/bi00560a012<http://c.acs.org/cyatb/511866/0/208052/20352/0/D/0/0/xivv.html>
Structure and Biological Activity of (-)-[3H]-Dihydroalprenolol, a Radioligand for Studies of β-Adrenergic Receptors <http://c.acs.org/cyatb/511866/0/208052/20353/0/D/0/0/xivv.html>
Malcolm H. Randall, Lawrence J. Altman, and Robert J. Lefkowitz
Journal of Medicinal Chemistry 1977
DOI: 10.1021/jm00218a020<http://c.acs.org/cyatb/511866/0/208052/20353/0/D/0/0/xivv.html>
Pharmacological Activity of Nitroxide Analogs of Dichloroisoproterenol and Propranolol <http://c.acs.org/cyatb/511866/0/208052/20354/0/D/0/0/xivv.html>
Elmer J. Rauckman, Gerald M. Rosen, and Robert J. Lefkowitz
Journal of Medicinal Chemistry 1976
DOI: 10.1021/jm00232a018<http://c.acs.org/cyatb/511866/0/208052/20354/0/D/0/0/xivv.html>
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