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SPORTS MEDICINE :
PHYSICAL EXERCISE AND FITNESS :
MEDICAL: CONDITIONS: OBESITY :
WOMEN:
Obesity Linked to Osteoporosis
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Obesity Linked to Osteoporosis
By David Liu, PHD
Food Consumer
http://www.foodconsumer.org/newsite/Non-food/Disease/
obesity_linked_to_osteoporosis_0923120250.html
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A shorter URL for the above link:
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http://tinyurl.com/9w4bs3e
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Sunday Sept 23, 2012 (foodconsumer.org) -- Women with obesity are at high
risk for osteoporosis, which a major cause for fractures, according to a
new study published in Journal of Back and Musculoskeletal Rehabilitation.
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snip
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Five independent factors, age, hypertension, smoking, exercise, and body
mass index were associated with osteoporosis. Obesity was linked with
higher risk for osteoporosis.
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The researchers concluded "In Southwest China, obesity increases the risk
of female osteoporosis. This finding provides a theoretical basis for its
prevention in developing countries."
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The complete article may be read at the URL above.
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Related:
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Review
Effects of obesity on bone metabolism
Jay J Cao
Correspondence: Jay J Cao [log in to unmask]
Author Affiliations
USDA ARS Grand Forks Human Nutrition Research Center
2420 2nd Ave N Grand Forks, ND 58202-9034, USA
Journal of Orthopaedic Surgery and Research 2011, 6:30
doi:10.1186/1749-799X-6-30
The electronic version of this article is the complete one
and can be found online at:
http://www.josr-online.com/content/6/1/30
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Obesity is traditionally viewed to be beneficial to bone health because of
well-established positive effect of mechanical loading conferred by body
weight on bone formation, despite being a risk factor for many other
chronic health disorders. Although body mass has a positive effect on bone
formation, whether the mass derived from an obesity condition or excessive
fat accumulation is beneficial to bone remains controversial. The
underline pathophysiological relationship between obesity and bone is
complex and continues to be an active research area. Recent data from
epidemiological and animal studies strongly support that fat accumulation
is detrimental to bone mass. To our knowledge, obesity possibly affects
bone metabolism through several mechanisms. Because both adipocytes and
osteoblasts are derived from a common multipotential mesenchymal stem
cell, obesity may increase adipocyte differentiation and fat accumulation
while decrease osteoblast differentiation and bone formation. Obesity is
associated with chronic inflammation. The increased circulating and tissue
proinflammatory cytokines in obesity may promote osteoclast activity and
bone resorption through modifying the receptor activator of NF-?B
(RANK)/RANK ligand/osteoprotegerin pathway. Furthermore, the excessive
secretion of leptin and/or decreased production of adiponectin by
adipocytes in obesity may either directly affect bone formation or
indirectly affect bone resorption through up-regulated proinflammatory
cytokine production. Finally, high-fat intake may interfere with
intestinal calcium absorption and therefore decrease calcium availability
for bone formation. Unraveling the relationship between fat and bone
metabolism at molecular level may help us to develop therapeutic agents to
prevent or treat both obesity and osteoporosis.
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snip
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Received:
30 April 2010
Accepted:
15 June 2011
Published:
15 June 2011
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Sincerely,
David Dillard
Temple University
(215) 204 - 4584
[log in to unmask]
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