Hi Yarrow,
You can use the likes of areaimol to calculate the surface accessible area, with or without accounting for crystal symmetry: http://www.ccp4.ac.uk/html/areaimol.html
There are other alternatives, but I hope that helps,
Rob
On 8 Sep 2012, at 00:37, Yarrow Madrona wrote:
> I have a buried active site and would like to determine if there is room
> for a water molecule in various mutants. Does anyone know of a good
> program to calculate this? I have heard of GRID and VOID but have never
> used them.
>
> Thanks.
>
>
> --
> Yarrow Madrona
>
> Graduate Student
> Molecular Biology and Biochemistry Dept.
> University of California, Irvine
> Natural Sciences I, Rm 2403
> Irvine, CA 92697
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