Zitat von Sudipta Bhattacharyya <[log in to unmask]>:
> Dear all,
>
> I have biochemically characterized one enzyme that can dephosphorylate
> NADP+ / NADPH. Recently, I have also solved the crystal structure of the
> protein with bound NADP+. The important thing is that, the protein do not
> have the Rossmann fold or the dinucleotide binding fold. Can any one please
> cite or suggest any other example of such type of anomaly? Is there any
> example of non-classical Rossmann fold bearing proteins?
>
> Thanks,
> Sudipta.
>
Dear Sudipta,
AKR enzymes (aldo/keto reductases; see www.med.upenn.edu/akr/ and
www.ncbi.nlm.nih.gov/pubmed/20887732) bind NAD(P) and have an
(alpha/beta)8 barrel motif.
Best wishes,
Karsten Niefind
-------------------------
Karsten Niefind, PhD
University of Cologne
Department of Chemistry
Otto-Fischer-Str. 12-14
D-50674 Cologne
Tel.: +49 (0)221 4706444
Fax: +49 (0)221 4703244
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