Basic Gene Mapping Course
November, 26-30, 2012
Max Delbrück Center (MDC) for Molecular Medicine
Berlin, Germany
The tenth annual gene mapping course will be held at the MDC in Berlin from November 26-30, 2012. The goal of the course is to teach the course participants both theory and application of methods for linkage analysis (parametric and nonparametric) and association studies. Additionally the use of exome sequence data to identify rare variants in families will be covered.
Emphasis of this course is on strategies for genetic mapping of human Mendelian and complex traits. It will include theory as well as practical exercises. The exercises will be carried out using a variety of computer programs (LINKAGE, GENEHUNTER, MERLIN, ALLEGRO, SIMWALK2, SLINK, PLINK, TAGGER, etc.) and with pencil and paper. TOPICS include: parametric methods (two-point and multipoint analysis); allele sharing (nonparametric) methods for sib-pairs and extended families (two-point and multipoint analysis); linkage admixture (heterogeneity); tagSNP selection, haplotype reconstruction, association studies (trios and case-control); data quality control; controlling for population admixture/substructure; sample size estimation and power estimation (extended families [simulation studies], sib-pairs and case-control data), using exome sequence data in families to identify rare variants, controlling the family wise error rate (FWER) and estimating empirical p-values. The organizers and instructors for the course are Suzanne Leal (Baylor College of Medicine) and Michael Nothnagel (Kiel University & Max Delbrück Center). The maximum number of participants is 30.
Application Deadline September 15, 2012
For additional information on the course, course schedule and application form please visit the course website: http://linkage.rockefeller.edu/suzanne/Berlin_Basic_Gene_Mapping_Course_2012.htm
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Suzanne M. Leal, Ph.D.
Professor
Director, Center for Statistical Genetics
Department of Molecular and Human Genetics
Baylor College of Medicine
One Baylor Plaza, 700D
Houston, TX 77030
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URL: www.bcm.edu/genetics/leal<http://www.bcm.edu/genetics/leal>
Administrative Assistant, Francoise Caro
Tel 1 713 798 8212<tel:1%20713%20798%208212>
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