On Tue, 2012-06-19 at 16:43 +0800, LISA wrote:
> Hi all,
>
> does anyone solve their structure by molecular replacement with
> phaser with LLG < 0?
> Thanks
>
> lisa
AFAIU, this means that your estimate of the solvent content is too low.
If you increase that, eventually you should get positive LLG. I've seen
negative LLGs appear for exactly this reason and eventually MR worked
even without adjustments. What matters most to me are Z-scores. or
rather if you have an outstanding solution in translation search.
--
"Hurry up before we all come back to our senses!"
Julian, King of Lemurs
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