This may well be an issue with the version of MATLAB. SPM is always slower on OS X due to the fact that MATLAB is not optimised for the platform. However, when I recently upgrade to R2012a from R2011a the impact on performance in SPM was really noticeable. If you can try downgrading to R2011a you may find things have improved. Thanks for the tip on the issues with LaTeX, I was finding the same problem when compiling the MEX files and am glad you have found a way to solve this.
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