Hi Jordan (I am having a deja-vue here ;),
the option refers to how the affine normalization is initiated: it is
regulated to use certain starting estimates and may not go too far
astray from those. The "no affine" option would not be my choice as this
will only do a non-linear normalization which usually does not account
for the bulk of the deformation (see the good old 1997 Ashburner paper).
The "no regularization" option does not set limits to what happens to
the brains during this step, which may also not be a good idea, and the
"average" option is meant to incorporate the fact that an average
template tends to be larger than the original one. If you use a
pediatric template I would therefore think that this would be a good
choice. If I understood this correctly, it will not use your template,
but frankly, I don't think this makes much of a difference in practice.
Cheers,
Marko
Jordan Larson wrote:
> Dear SPMers,
>
> I am interested in discovering the best option for affine regularisation
> in VBM8 Estimate and Write to use with pediatric brains. Is it better to
> use no affine, average sized, or no regularization? Does the average
> size regularization template use an average of normal adults or an
> average of my template?
>
> Jordan Larson
> Undergraduate Research Assistant
> Department of Psychology
> Southern Illinois University Carbondale
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____________________________________________________
PD Dr. med. Marko Wilke
Facharzt für Kinder- und Jugendmedizin
Leiter, Experimentelle Pädiatrische Neurobildgebung
Universitäts-Kinderklinik
Abt. III (Neuropädiatrie)
Marko Wilke, MD, PhD
Pediatrician
Head, Experimental Pediatric Neuroimaging
University Children's Hospital
Dept. III (Pediatric Neurology)
Hoppe-Seyler-Str. 1
D - 72076 Tübingen, Germany
Tel. +49 7071 29-83416
Fax +49 7071 29-5473
[log in to unmask]
http://www.medizin.uni-tuebingen.de/kinder/epn
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