On 11/01/11 16:32, Anastassis Perrakis wrote:
>
> An experiment that I would like to do as a structural biologist - is the following:
> What about adding an "increasing noise" model to the Fobs's of a few datasets
> and re-refining?
> How much would that noise change the final model quality metrics and in absolute
> terms?
The problem is that in practice, errors in the data will arise from systematic
errors as James Holton nicely sums up. It is hard to 'model' these. We really
need many test cases to improve data processing techniques. An interesting
suggestion mentioned along the thread was to create a data base of problematic
data, i.e containing non-explained peaks, diffuse streaks and strange reflection
profiles etc.
Needless to say, developers (and future PDB-REPROCESS initiatives) will benefit
from raw data deposition. We will have to establish if it is worth the money and
effort to deposit ALL raw data.
Loes.
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__________________________________________
Dr. Loes Kroon-Batenburg
Dept. of Crystal and Structural Chemistry
Bijvoet Center for Biomolecular Research
Utrecht University
Padualaan 8, 3584 CH Utrecht
The Netherlands
E-mail : [log in to unmask]
phone : +31-30-2532865
fax : +31-30-2533940
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