Hi, thanks for your reply. Yeah, of course, this would work
(hopefully). The reasons for perhaps using two tcICAs are that a) I
only have half the number of patients compared to controls (20 vs
~40), and there has been some dispute about whether this might throw
off balance across groups. Plus, b) the patients are quite severely
ill, so their RSNs might differ a lot (at least, that's what we
expect), and I am not exactly sure what a tcICA might make of that
when both groups are in the same analysis. What do you (and others)
think?
Cheers,
Cornelius
On Sat, Oct 8, 2011 at 10:22 PM, Benjamin Kay <[log in to unmask]> wrote:
> As you explained, running dual regression on two different sets of ICs
> presents a challenge. Why not do tcICA on data from both groups, together, and
> then launch your dual regression from there?
>
> On Saturday, October 08, 2011 16:16:41 you wrote:
>> Hi,
>>
>> it has been suggested on the list to generate a set of RSNs from the
>> "healthy" population and to run it against the "patient" group when
>> large differences are expected. That's what I am trying to do because
>> I have reason to assume so.
>> I imagine this means running tcICA on both the control and the patient
>> group separately and then (when calling the dual_regression script)
>> using melodic_IC.nii.gz from the control.gica on the .filelist from
>> the patient.gica - is that right? But how can I include possible
>> additional/specific artefacts represented in the patient
>> melodic_IC.nii.gz that might not necessarily be present or identical
>> in the control group in the analysis? Fslmerge the ICAs of interest
>> from the control melodic_IC into the patient melodic_IC and use that
>> instead (and possibly throw out ICAs from the patient melodic_IC that
>> look similar beforehand)? Did anyone do this succesfully and can
>> advise?
>> Thanks a lot,
>> Cornelius
>
--
Dr. med. Cornelius J. Werner
Department of Neurology
RWTH Aachen University
Pauwelsstr. 30
52074 Aachen
Germany
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