Hello,
I ran the T1 images of two groups (PBD vs HC) through segmentation using FSL- FIRST and then did vertex analysis. There were fairly large group differences for some of the individual structures (green-blue range coloring = higher statistical significance), but after running multiple comparison correction (FDR or Fthresh), all of the structures were solid red, which according to the instructions means that none of the differences were significant. The red color corresponded to a value of 2, however, on the scale when I view it in FSLview (not 0 as the guide shows). If all of my structures are entirely red, does this indeed mean that none of the differences between the group's structures are significant? Has anyone else had this problem where before multiple comparison correction the differences had a fairly large statistical significance that would presumably pass multiple comparison correction, but then after running multiple comparison corrections all of the structures showed no statistical significance? My group sizes are 47 for HC and 48 for PBD.
Thanks for your help!
Bryn
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