Dear FSL experts,
I am performing a study with TBSS.
My pathological group did not show significant differences analysing FA
(although there are trends between 0.06 and 0.08 TFCE corrected that show
decreased FA) or MD, but I have found 4 clusters (more than 100 voxel) of
increased L1. In order to better understand this result I have decided to
analyse the mode of anisotropy (MO file).
My questions are:
may I use TBSS to analyse MO?
I have read a paper of Gwenaƫlle about MCI where a voxel-based approach
has been used for MO files. Is this always more correct or it has been
used because of the particular population? IN the case of voxel-based
analysis, do I need to smooth the images and how much? do I need to use a
mask excluding gray matter or do I perform a whole-brain analysis?
any help or suggestion is welcome!
Angela
Angela Favaro, MD, PhD
Psychiatric Clinic
Department of Neurosciences
via Giustiniani 3
35128 Padova
Italy
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