Hi Ben,
> we used fMRI to compare differences between one brain-lesioned
> patient and a group of 12 healthy controls. Findings from a pooled
> 2-sample t-test revealed two regions of higher activity in the
> patients within the task related network. It would be an interesting
> question to investigate whether these two regions were most strongly
> connected within the controls. Would a connectivity analysis
> incorporating only 12 subjects make sense? Are there other
> methodological approaches to test our hypothesis?
As a note of caution, we only recently tried something similar and found
interesting correlations between functional connectivity and a marker of
clinical impairment, which, however, were fully explained by looking at
the GM volume deficits in the patients. We felt that not taking into
account structural differences between groups may lead to potentially
erroneous conclusions. See http://dx.doi.org/10.1002/hbm.21227
Cheers,
Marko
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PD Dr. med. Marko Wilke
Facharzt für Kinder- und Jugendmedizin
Leiter, Experimentelle Pädiatrische Neurobildgebung
Universitäts-Kinderklinik
Abt. III (Neuropädiatrie)
Marko Wilke, MD, PhD
Pediatrician
Head, Experimental Pediatric Neuroimaging
University Children's Hospital
Dept. III (Pediatric Neurology)
Hoppe-Seyler-Str. 1
D - 72076 Tübingen, Germany
Tel. +49 7071 29-83416
Fax +49 7071 29-5473
[log in to unmask]
http://www.medizin.uni-tuebingen.de/kinder/epn
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