Hi Suchada,
The influence on cross terms heavily depends on the utilized sequence, as well as on the spatial orientation of the diffusion with respect to the imaging gradients. I would think that protocols with large number of datapoints suffer less from these problems. If you are concerned though, there are some relatively easy workarounds to reduce the effect size of cross-terms. Look for geometric averaging in
http://onlinelibrary.wiley.com/doi/10.1002/cmr.a.20031/abstract
Cheers,
Stam
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