But you have to do solvent flattening (density modification), which people often (unintentionally?) skip for structures solved with molecular replacement. Please correct me if I am wrong.
Clement
On May 24, 2011, at 6:01 PM, [log in to unmask] wrote:
> This is not my experience. Provided the solvent is featureless, I find
> that a high solvent contents leads to a lower Rfree due to a kind of
> solvent flattening effect. Of course, if a significant part of the
> molecule(s) is/are disordered, this will lead to a degradation of the
> Rfree.
>
> My 2 cents,
> Herman
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