Post-doc position available: Development of methods, algorithms and tools for understanding complex trait genetics

We are looking for a Post-doc to join our young and growing group. We provide a supportive environment and strongly believe in an interdisciplinary approach, so we encourage applicants with a non-standard background to apply. We are based in Uppsala, Sweden at the Swedish University of Agricultural Sciences and also have links with Uppsala University.

Our group use a Computational Genetic approach to understand the mechanisms by which heritable genetic variation regulate phenotypic expression in
individuals and populations. As input we use empirical data from experimental or natural populations that have been characterized phenotypically and genetically (e.g. genome resequencing and high-density genotyping). The focus of this post will be to develop methods, algorithms, tools and software for using modern genetics data to understand complex trait genetic inheritance. For this work you will need a strong background in informatics (one or several of the disciplines mathematics, statistics, computer science, programming or bioinformatics) as well as a thorough theoretical background in genetics.

Aside from work, you will have the chance to get to know Uppsala, which is a pretty university town, notable for its castle and cathedral. It is 40 minutes by train from Stockholm. We get some snow in winter and beautiful long summer days.

Qualifications A successful applicant should have relevant scientific education, have programming experience, be highly motivated for research and have an interest in molecular, quantitative and computational genetics. A strong mathematical/statistical background is advantageous.

Forms for funding or employment Employment as Post-doctoral researcher student for 1 year with possibility of extension 1+2 years.

If you have questions about us or our work, please contact Örjan Carlborg ([log in to unmask]) or Ronnie Nelson ([log in to unmask]). You can also find more information about our group at http://www.computationalgenetics.se

We are looking forward to hearing from you!

Selected recent publications:

Carlborg, Ö. and Haley, C. Epistasis: too often neglected in complex traits studies? Nature Reviews Genetics 2004 5:618-625.

Carlborg, Ö., Jacobsson, L., Åhgren, P., Siegel, P., Andersson, L. Epistasis and the release of genetic variation during long-term selection. Nature Genetics 2006 38:418-20.

Le Rouzic, A., Siegel, P. and Carlborg, . Phenotypic Evolution from Genetic Polymorphisms in Radial Network Architectures. BMC Biology 2007, 5:50.

Alvarez-Castro, J., le Rouzic, A. and Carlborg, Ö. How to perform meaningful estimates of genetic effects. PLOS Genetics 2008 May 2;
4(5):e1000062 Le Rouzic, A., Alvarez-Castro, J. and Carlborg, Ö. Dissection of the genetic architecture of body weight in chicken reveals the impact of
epistasis on domestication traits. Genetics 2008 179:1591-1599.

Rubin CJ, Zody MC, Eriksson J, Meadows JR, Sherwood E, Webster MT, Jiang L, Ingman M, Sharpe T, Ka S, Hallböök F, Besnier F, Carlborg Ö, Bedhom B,
Tixier-Boichard M, Jensen P, Siegel P, Lindblad-Toh K, Andersson L. Whole genome resequencing reverals loci under selection during chicken
domestication. Nature. 2010 Mar 25;464(7288):587-91. Epub 2010 Mar 10.

Johansson AM, Pettersson ME, Siegel PB, Carlborg Ö (2010) Genome-Wide Effects of Long-Term Divergent Selection. PLoS Genet 6(11): e1001188.
doi:10.1371/journal.pgen.1001188

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