Dear SPMers
Newbie with silly questions here. I'm running a SPM8 VBM study on sleep disturbances comparing a group of MRIs from 31 insomniacs vs. 113 subjects with normal sleep. All non-demented. I have more or less followed the steps of Dr. Ashburner tutorial:
reorient-> -segment-> create a single template for the 144 subjects -> smooth.
For the analysis we have run a two sample t-test controlling for age and total volume (groups were not different in gender). We have found some differences between insomniacs and normals but we wonder if this differences could be explained by the different size of each group. Should we use two groups of 31 subjects instead?
Also, should we create a new template for this analysis or can we use the template that we used for the former study with the new one? Or is it better to use a pre-existing template?
Ricardo Osorio
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