Dear colleagues,
One 3-year PhD studentship is open at the Chemistry Department of Ecole Normale Supérieure (Paris, France; see http://www.chimie.ens.fr/PhotochimieUltrarapide/UltrafastPhotochemistry).
The subject is the study of the primary mechanism of DNA photorepair by (6-4) photolyases, using femtosecond optical spectroscopy. Starting date: September 1st, 2011. Net allowance: about 1370 € monthly.
Photolyases are photoactive proteins able to absorb blue light thanks to a flavin cofactor and to use the absorbed energy to repair DNA lesions (pyrimidine dimers) produced by exposition to UV light. The interest will be focused on (6-4) photolyases and the corresponding lesions, in collaboration with Osaka University and CEA-Saclay (France). The objective will be to study the dynamics of the photorepair process, by means of femtosecond transient absorption spectroscopy and time-resolved fluorescence spectroscopy. One will in particular study electron transfer from the reduced flavin cofactor of the enzyme to the dimer, splitting of the dimer and restoring of the intact nucleobases.
Applications are invited from students with MSc, preferably having a solid background in physical chemistry and interested in time-resolved spectroscopy applied to biomolecules. To apply please send a CV, a motivation letter and details of two referees to: [log in to unmask]
For more information contact: Dr. Pascal Plaza, Tel. +33 144322414
Information on the studentship (in French): http://www.enseignementsup-recherche.gouv.fr/cid20185/doctorat.html#Le%20contrat%20doctoral
We thank you for your help in sending this announcement to potential candidates.
Best regards.
Pascal Plaza
Groupe de Photochimie Ultrarapide
UMR8640
Département de Chimie
Ecole Normale Supérieure
24 rue Lhomond
75005 Paris
Tel: 01 44 32 24 14
http://www.chimie.ens.fr/PhotochimieUltrarapide
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